Matthew Perry’s final days were a mix of nicotine lollipops, ketamine and testosterone shots that left him ‘angry and mean’



Matthew Perry’s autopsy report revealed a grimmer look at the star’s final days.

The report, obtained by Page Six on Friday, revealed that a female friend of the actor said he was “angry and mean” in the weeks before his death because he had been taking testosterone shots.

The eye-opening report noted that aside from a lethal amount of ketamine mixed with the opioid-like drug buprenorphine, which is used to alleviate pain and help with addiction to opioids, Perry had been taking Tammoxifen to lose weight, antidiabetic medication and nicotine lollipops.

Before his death, he was trying to quit smoking. His live-in assistant said he had been smoking about two packs of cigarettes per day.

In addition to the testosterone, Perry had been taking Tammoxifen to lose weight, antidiabetic medication and nicotine lollipops before his Oct. 28 death. Getty Images
Furthermore, the report states that there were “multiple open, empty, half-filled medication bottles” prescribed to him in his live-in assistant’s bedroom. Youtube

The medical examiner’s report further exemplified how heavily Perry relied on prescribed and over-the-counter medication to maintain his quality of life.

“In the assistant’s bedroom, there were multiple open, empty, half-filled medication bottles prescribed to the decedent, as well as over-the-counter medications, vitamins, digestive aids and dishes filled with multiple various loose pills, tablets, caplets, candy and breath mints,” the report read.


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“Over-the-counter medications, vitamins, digestive aids and dishes filled with multiple various loose pills, tablets, caplets, candy and breath mints” were also found. Getty Images

In Perry’s bathroom, there were “prescribed ointments, digestive aids and oral rinses.”

The “Friends” star had been receiving ketamine infusions regularly before his death, but the report noted that the ketamine found in his body came from elsewhere.

His last infusion occurred a week and a half before he died, and its half-life is only three to four hours.

Perry, who died at the age of 54, had ended ketamine treatments a week and a half before his death, the report notes. REUTERS
However, he died of the “acute effects of ketamine.” Los Angeles Times via Getty Images

“It is more likely this was recreational ketamine use,” Dr. Bankole Johnson, one of the top neuroscientists and physicians in the world, told Page Six exclusively Friday.

“It would be questionable medicine to provide ketamine to someone also using buprenorphine — a true recipe for disaster.”

Perry had previously written about his dislike of ketamine in his 2022 memoir “Friends, Lovers, and the Big Terrible Thing: A Memoir,” saying he often felt like he was “dying” during the treatments he received while staying at a Swiss rehab during the pandemic.

“It is more likely this was recreational ketamine use,” Dr. Bankole Johnson told Page Six. GC Images

“Taking K is like being hit in the head with a giant happy shovel. But the hangover was rough and outweighed the shovel,” he penned.

“Ketamine was not for me.”

In fact, Perry was supposed to be off his infusions before he died, as his anesthesiologist Dr. Ataoin (whose name was partially redacted in the autopsy report)‚ said he no longer needed the treatments because “his depression was fine.”

Perry was thought to have been sober at the time of his death. TheImageDirect.com
He publicly struggled with his sobriety for his entire adult life, once revealing he spent $9 million to help himself beat his addiction. GC Images

Furthermore, the unnamed female to whom the medical examiner spoke said the beloved actor was even in “good spirits” during their final conversation that took place days before his death.

This corroborates Jennifer Aniston’s story, who said she spoke to Perry the morning of Oct. 28, hours before his assistant found him face-down in the pool of his $4 million Hollywood mansion.

“He had quit smoking. He was getting in shape. He was happy — that’s all I know,” she told Variety following his death.

An unnamed female colleague of Perry’s said in the medical report that he appeared to be in a positive state of mind before his death. Getty Images

“I was literally texting with him that morning, funny Matty.”

“He was not in pain. He wasn’t struggling. He was happy.”

Perry, who revealed in 2022 he spent about $9 million trying to stay sober throughout his life, wanted to be remembered not as Chandler Bing, his iconic “Friends” character, but as someone who helped guide people through their addictions.

Perry would like to be remembered as someone who helped others with their addictions. ©Warner Bros/Courtesy Everett Collection

“The best thing about me, bar none, is that if somebody comes to me and says, ‘I can’t stop drinking, can you help me?’ I can say ‘yes’ and follow up and do it,” he proudly stated on the “Q with Tom Power” podcast in 2022.

He founded the Perry House in 2013 to help people stay sober and had plans to launch a foundation before his passing.

The Matthew Perry Foundation was launched in his honor days after he died.



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